This chapter identifies and discusses a ‘top five’ list of central obstacles to the improvement of regime effectiveness and related important institutional cures and techniques and discuss, and subsequently applies this framework in an analysis of the CLRTAP regime. The main conclusion is that CLRTAP has been cleverly designed, not least with regard to its strong focus on knowledge development and its dynamic and gradual style of development, differentiating and strengthening commitments as knowledge has improved and better technologies have become available. This has in turn led to the problems addressed by the regime becoming less malign over time. So there has been important internal interaction effects. Important external interaction has also taken place. Related policy development and implementation within the EU has become crucially important to bring into the causal picture.